| Response after One Dose of a Monovalent Influenza A (H1N1) 2009 Vaccine — Preliminary Report
From Abstract:
Background A novel influenza A (H1N1) 2009 virus is responsible for the first influenza pandemic in 41 years. A safe and effective vaccine is urgently needed. A randomized, observer-blind, parallel-group trial evaluating two doses of an inactivated, split-virus 2009 H1N1 vaccine in healthy adults between the ages of 18 and 64 years is ongoing at a single site in Australia.
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Results By day 21 after vaccination, antibody titers of 1:40 or more were observed in 116 of 120 subjects (96.7%) who received the 15-µg dose and in 112 of 120 subjects (93.3%) who received the 30-µg dose. No deaths, serious adverse events, or adverse events of special interest were reported. Local discomfort (e.g., injection-site tenderness or pain) was reported by 46.3% of subjects, and systemic symptoms (e.g., headache) by 45.0% of subjects. Nearly all events were mild to moderate in intensity.
Conclusions A single 15-µg dose of 2009 H1N1 vaccine was immunogenic in adults, with mild-to-moderate vaccine-associated reactions.  story continues..comments?
WASHINGTON (Reuters) - The discovery of immune system particles that attack the AIDS virus may finally open a way to make a vaccine that could protect people against the deadly and incurable infection, U.S. researchers said on Thursday. They used new technology to troll through the blood of 1,800 people infected with the AIDS virus and identified two immune system compounds called antibodies that could neutralize the virus. And they found a new part of the virus that the antibodies attack, offering a new way to design a vaccine, they reported in the journal Science. » www.reuters.com/article/scienceN···enceNewscomments?
It is the first gene clue to the condition in 16 years and has prompted scientists to rethink their theories on how the disease develops. The genes were pinpointed in a study of 16,000 DNA samples and are known to be implicated in inflammation and cholesterol breakdown. It is hoped the Nature Genetics study will open the way for new treatments. » news.bbc.co.uk/2/hi/health/8237686.stmcomments?
Scientists have been trying to get an accurate estimate of the mutation rate for over 70 years.
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However, next generation sequencing technology has enabled the scientists to produce a far more direct and reliable estimate. story continues..comments?
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