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Ambients Virtual Weather Station
Lots of plugins here including up to the second uploading to your webpage with add-ons like Weather Flash.
Another popular desktop weather station program
Lacross Technology Heavy Weather
This is the software that comes with their weather stations
David Instruments WeatherLink
Software for Davis Weather stations that have the optional Data Logger.
Open2300 software for La Crosse 2300 series
Runs on Linux. Can be used for Weather Underground and CWOP updates.
I'm running "WeatherView" on Linux for my Davis Vantage Pro2. It works great, and is under active development. The developer is a pretty OK guy, and the forum for it is a nice place to get help.