Yes. Anyone can moderate a game of mafia. However, it is recommended (not mandatory) that you have played several games first before trying to tackle moderating a game yourself.

Moderating a game requires knowledge of the inner workings of the game. You need to be sure to balance the sides (Pro-Town & Anti-Town) and sometimes that is not so easy when you have not played enough games yourself.

If you are interested in trying your hand at moderating a game, simply post a sign up thread in the forum using the [Signup] tag, the game number and name (if you choose to name it) and wait until the required number of players have shown interest in your game. It is not mandatory, but it is helpful upon reaching the chosen amount of players if you also include a link to the game thread in the sign up thread.