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For those driven by the biological science we are putting a huge effort into the elucidation of the pathways underlying TSC and the identification of the best targets (see Rothberg Courage Awards, with labs now going at Harvard, Yale, Fox Chase).

For those driven by the computational chemistry, and physics we are going to sponsor a $1,000,000 prize. We also are unique in that we are sharing our results in real time to make sure everyone can use them, and updating our discoveries on the pathways as fast as we can post them. We are also exploiting the best in genomics, computational chemistry, and informatics, and have created the first non-profit "chemical genomics" institute.

In molecular biology, computer science, and chemistry we are looking for full time people to come join the institute, and part time help.

For those that care about cancer, and this is a big statement, we feel that the focus of this program on the BEST science will have potentially a huge direct impact on the understanding of cancer and cancer drugs. Both because TSC causes many pre-cancers in many different organs (and some cancers) and because we are following up and testing all the drugs we get both on TSC and on cancers.

So if you care about breast, brain, lung, pancreatic, kidney, blood, or other cancers you should know that all cancers, and there are more then 200, share a small set of underlying "mechanisms" that they use to kill you. Our work on TSC is designed to understand this fundamental basis, and cut through this noise that has prevented the war on cancer from ending successfully.

For those that care about TSC. I am privileged to have seen the light on the end of the tunnel that technologies coming out of the genomics revolution, the computing revolution, and the chemistry revolution can produce. With focus we will make a difference, as a team we will have the resources to solve this problem.

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