Boulder City, NV
reply to bruin23
Re: Driving to Vegas on Memorial Day Weekend If you are staying at a Vegas hotel, does it offer early check in? If so, I like to leave L.A. early as to make it to Vegas by noon or 1pm.
Most of the traffic you may encounter will be in the L.A. basin. You could take the 405 N to the 101/134/210 and hit the 15 from there. Otherwise you will be going down the 10 E through downtown to the 60 (my preference) or remain on the 10 E to the 15 N.
I wouldn't leave at 3 before a major holiday weekend. This drive is normally a 4 hour affair assuming moderate traffic in L.A. and no major accidents on the 15 North, leaving early minimizes potential delays and gives you time to check in a relax a little at the pool from the drive. May make for a more enjoyable experience.