said by DKS:
Nothing. Do absolutely nothing. Just don't run defrag and don't even "align" the drive. Just let it run.
That's probably the best advice offered in this thread.
I'd also suggest a RAM drive for temporary internet files using the free Dataram RAMdisk, to help against wear levelling and speed things up, or if using Firefox just turn off the disk cache and crank up the memory cache in about:config.
Intel also recommends disabling Superfetch / Prefetch.