One or both of the two drivers may not be digitally signed or corrupted.
I would suggest to go ahead and remove the two entries to prevent these two drivers form loading.
You can actually remove the LowerFilters and UpperFilters values completely as these values are not present by default.
There is a Microsoft Support Article on this issue - click the solution under "Let me fix it myself":
The article also applies to Windows 8.
If you have an application that uses either of these drivers such as iTunes which uses the GEARAspiWDM.sys you may have to reinstall that application for the software to work properly.
Make sure you have the latest version of the software you need to reinstall.
If the problem then re-occurs may sure you have the latest version of the driver causing the issue.
For GearaspiWMD.sys install the latest Gear driver:
For PxHlpa64.sys contact Roxio or Dell, if applicable, for the applicable PX Engine update.