MONDAY, Jan. 7 (HealthDay News) -- An international team of scientists has pinpointed 480 genes that play a role in cell division, and in the process they also discovered that more than 100 of those genes show an abnormal pattern of activation in cancer cells.

The findings are published in this week's issue of the Proceedings of the National Academy of Sciences.

The American, German and Israeli scientists, who used computational biology techniques to pinpoint the genes, noted that many cancer studies seek to identify "missing" genes that might cause cancer. This study shows that genes can contribute to cancer in less obvious ways.

"What we see is that there are many genes that are present and yet still involved in cancer, because they are not activated, or expressed, in the way they normally are," study co-author Itamar Simon, a molecular biologist at Hebrew University Medical School in Israel, said in a prepared statement.

Instead of the normal cycling on and off during cell replication and development, these genes are expressed continuously or not at all, Simon explained.

A few of the genes identified by Simon and his colleagues have previously been linked to cancer, but most haven't, including at least three genes responsible for repairing genetic mutations that occur as DNA is replicated in a cell

Spotted here