Copy and paste the text in the box below to notepad and save it to your desktop as fix.reg, then locate the fix.reg file you saved, double-click it to run it and ok it merging to the registry:
REGEDIT4
[-HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\URLSearchHooks]
[HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\URLSearchHooks]
"{CFBFAE00-17A6-11D0-99CB-00C04FD64497}"=""
Reboot, scan again with Hijack This and post a new log here.
Is this something you recognize - O4 - Startup: Shortcut to Manman.R1W.lnk = C:\Documents and Settings\mrhodes\Desktop\Manman.R1W ?